| 2007.167.N - Lung Cancer (NSCLC) and the effects of Chemotherapy with or without Bevacizumab
|
| This randomized phase III trial is studying chemotherapy and bevacizumab to see how well they work compared to chemotherapy alone in treating patients with stage IB, stage II, or stage IIIA non-small cell lung cancer that was removed by surgery. |
| |
| 2007.182.C - Colon Cancer - are there molecular causes for recurrence?
|
| The study is trying to determine why some sage II colon cancers recur and some do not. The study is examining if the behavior of stage II colon cancers can be predicted by the activity of its genetic make-up. The study will measure whether the activity of different sets of genes can allow doctors to predict things about how tumor cells will behave and be affected by treatments. The study will also follow patient out comes for recurrance for upto 3 years after surgery. |
| |
| 2008.014.N - Kidney Cancer and the effects of Sunitinib and Sorafenib
|
| To determine if drugs Sunitinib or Sorafenib can prevent recurrence of kidney cancer and to compare the effects of Sunitinib, Sorafenib, or the placebo on kidney cancer and the participant. |
| |
| 2008.124.N - Rectal Cancer and the effects of Laparoscopic-Assisted vs Open Resection
|
| This randomized phase III trial is studying laparoscopic-assisted resection to see how well it works compared with open resection in treating patients with stage IIA, stage IIIA, or stage IIIB rectal cancer. |
| |
| 2008.127.N - Lung Cancer and a Comparison of Different Types of Surgery
|
| This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer. Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy is more effective than lobectomy in treating stage IA non-small cell lung cancer. |
| |
| 2009.009.N -NCCTG N0574 - Brain Cancer and the effects of Stereotactic Radiation Therapy
|
| Stereotactic radiation therapy can send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether stereotactic radiation therapy is more effective with or without whole-brain radiation therapy in treating patients with brain metastases. |
| |
| 2009.037.A - Identifying colorectal cancer cells that are resistant to treatment and may cause recurrence
|
| The study is trying to determine why some colorectal cancers recur and some do not. The study is examining how to identify some cells which are resistant to current treatments. Once these cells can be reliably identified, new ways to treat these cells will be explored. |
| |
| 2009.096.A - Leukemia and the effects of Lenalidomide as Maintenance Therapy (The CONTINUUM Trial)
|
| The purpose of this study is to determine if lenalidomide (Revlimid®) is safe and effective as a maintenance therapy at improving further the quality of the response you achieved with your last therapy and at prolonging the duration of your response. This study will compare the effects (good and bad) of lenalidomide with the dummy drug. |
| |
| 2009.127.B - Metastatic Breast or Prostate Cancer, or Multiple Myeloma With Bone Involvement and the effects of Zoledronic Acid
|
| This randomized phase III trial is studying two different schedules of zoledronic acid to compare how well they work in treating patients with metastatic breast cancer, metastatic prostate cancer, or multiple myeloma with bone involvement. |
| |
| 2009.128.B - Bone Metastases, Osteonecrosis of the Jaw and the effects of Zoledronic Acid
|
This clinical trial is studying osteonecrosis of the jaw in patients with cancer who are receiving zoledronic acid for bone metastases.
|
| |
| 2009.138.N - Esophageal Cancer and the effects of Cetuximab
|
| This randomized phase III trial is comparing how well giving paclitaxel and cisplatin together with radiation therapy works with or without cetuximab in treating patients with locally advanced esophageal cancer. |
| |
| 2010.011.N - Prostate Cancer and the effects of Radiation Therapy with or without Androgen-Deprivation Therapy
|
| This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer. |
| |
| 2010.012B - Breast Cancer and the Effects of Paclitaxel, Carboplatin, and Panitumumab
|
| This phase II trial is studying the side effects and how well paclitaxel and carboplatin together with panitumumab works in treating patients with metastatic triple negative breast cancer. |
| |
| 2010.033.C - Lung Cancer and the effects of Seneca Valley Virus-001 after Chemotherapy
|
| This randomized phase II trial is studying NTX-010 to see how well it works compared with a placebo when given after chemotherapy in treating patients with extensive-stage small cell lung cancer. |
| |
| 2010.040.N - NSABP B-43 - Ductal Carcinoma In Situ and the effects of Radiation Therapy with or without Trastuzumab
|
| This randomized phase III trial is studying radiation therapy to see how well it works compared with or without trastuzumab in treating women with ductal carcinoma in situ who have undergone lumpectomy. |
| |
| 2010.061.A - Colon Cancer and the effects of Rosuvastatin
|
| This randomized phase III trial is studying rosuvastatin to see how well it works compared with placebo in treating patients with stage I or stage II colon cancer that was removed by surgery. |
| |
| 2010.064.B - Leukemia and the effects of Pentostatin, Cyclophosphamide, and Rituximab followed by Alemtuzumab
|
| This phase II trial is studying how well pentostatin, cyclophosphamide, rituximab, and alemtuzumab work in treating patients with relapsed or refractory B-cell chronic lymphocytic leukemia. |
| |
| 2010.067.N - Non-Hodgkin's Lymphoma and the effects of Rituximab and Combination Chemotherapy
|
| This randomized phase III trial is studying rituximab when given together with two different combination chemotherapy regimens to compare how well they work in treating patients with diffuse large B-cell non-Hodgkin's lymphoma. |
| |
| 2010.084.N - Pancreas and the effects of Erlotinib and Chemoradiation
|
| This randomized phase III trial is studying gemcitabine hydrochloride and erlotinib hydrochloride to see how well they work compared with gemcitabine hydrochloride alone followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil in treating patients with pancreatic cancer that was removed by surgery. |
| |
| 2010.096.N - Liver Cancer and the effects of Sorafenib Tosylate and Doxorubicin Hydrochloride
|
| Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving sorafenib tosylate together with doxorubicin hydrochloride is more effective than sorafenib tosylate alone in treating liver cancer. |
| |
| 2010.100.A - Cholangiocarcinoma and the effects of Capecitabine, Gemcitabine, and Radiation Therapy
|
| This phase II trial is studying how well giving capecitabine together with gemcitabine followed by capecitabine and radiation therapy works in treating patients with cholangiocarcinoma of the gallbladder or bile duct. |
| |
| 2010.113.B - Hodgkin Lymphoma and the effects of Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy
|
| This phase II trial is studying fludeoxyglucose F 18-PET/CT imaging to see how well it works in assessing response to combination chemotherapy and allow doctors to plan better additional further treatment in treating patients with stage III or stage IV Hodgkin lymphoma. |
| |
| 2010.116.C - Breast Surgery and a comparison between 2 methods of locating the nerve space for local anesthestic injection
|
| The purpose of this study is to compare ultrasound and predetermined distance techniques for finding the paravertebral space to inject local anesthetic (numbing medicine) when you are given anesthesia for surgery. |
| |
| 2010.137.N - Endometrial Cancer and the effects of Pelvic Radiation Therapy vs. Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin
|
| This randomized phase III trial is studying pelvic radiation therapy to see how well it works compared with vaginal implant radiation therapy, paclitaxel, and carboplatin in treating patients with high-risk stage I or stage II endometrial cancer. |
| |
| 2010.151.N - Colorectal Cancer and the Effects of Chemotherapy and Bevacizumab
|
| This randomized phase III trial is studying giving combination chemotherapy and bevacizumab together before and after surgery to see how well it works compared to giving combination chemotherapy and bevacizumab together after surgery in treating patients with colorectal cancer with liver metastases that could be removed by surgery. (Bevacizumab treatment closed as of 11/15/2010). |
| |
| 2010.154.N - Lung Cancer and the effects of Carboplatin and Paclitaxel with or without Bevacizumab and/or Cetuximab
|
| This randomized phase III trial is studying carboplatin and paclitaxel to compare how well they work with or without bevacizumab and/or cetuximab in treating patients with stage IV or recurrent non-small cell lung cancer. |
| |
| 2010.156.N - Colon Cancer and the effects of Celecoxib
|
| This randomized phase III trial is studying giving oxaliplatin, leucovorin calcium, and fluorouracil together to compare how well they work when given together with or without celecoxib in treating patients with stage III colon cancer previously treated with surgery. |
| |
| 2010.170.N - Lung Cancer (NSCLC) and the effects of Bevacizumab or Pemetrexed Disodium with Induction Therapy
|
| This randomized phase III trial is studying bevacizumab and pemetrexed disodium alone or in combination after induction therapy to see how well they work in treating patients with advanced non-squamous non-small cell lung cancer. |
| |
| 2010.172.N - Small-Cell Lung Cancer Receiving and the Effects of Radiation Therapy Regimens
|
This randomized phase III trial is comparing three different chest radiation therapy regimens to see how well they work in treating patients with limited-stage small cell lung cancer.
|
| |
| 2010.184.A - Pancreatic Cancer and the Effects of HyperAcute®-Pancreas Immunotherapy
|
| The purpose of this study is to assess overall survival after treatment with a regimen of adjuvant therapy (Gemcitabine alone or with 5-FU chemoradiation) with or without HyperAcute®-Pancreas (algenpantucel-L) immunotherapy in subjects who have undergone surgical resection. |
| |
| 2010.207.B - Carcinoma of the Lung and the Safety of Crizotinib & Pemetrexed with Cisplatin vs Carboplatin
|
| This study will evaluate the anti-cancer effects of crizotinib, an oral medication, when compared with standard chemotherapy in patients with ALK positive lung cancer. |
| |
| 2010.208.N - Prostate Cancer (with a Rising PSA After Radical Prostatectomy) and the effects of Short-Term Androgen Deprivation With Pelvic Lymph Node or Prostate Bed-Only Radiotherapy (SPPORT)
|
This randomized phase III trial is studying prostate radiation therapy to see how well it works compared with short-term androgen deprivation therapy given together with pelvic lymph node radiation therapy with or without prostate radiation therapy in treating patients with a rising PSA after surgery for prostate cancer.
|
| |
| 2011.005.A Invasive Breast Cancer and the Use of F-18-FLT to Help Predict Tumor Changes
|
| When [F-18] FLT is used during positron emission tomography (PET) imaging, it may produce images that will provide useful information about the tumor's response to treatment. It is hoped that [F-18] FLT PET imaging performed before and during the course of your chemotherapy treatments will help to monitor your tumor status and show whether your tumor is growing or shrinking. |
| |
| 2011.047.A - Breast Cancer and the Effects of Capecitabine
|
| The objective of this phase-III trial is to compare the efficacy and safety of sorafenib in combination with capecitabine versus capecitabine in combination with placebo in the treatment of subjects with locally advanced or metastatic HER2-negative breast cancer who are resistant to or have failed prior taxane and an anthracycline or for whom further anthracycline therapy is not recommended. |
| |
| 2011.047.A HER2-negative breast cancer and the effects of capecitabine plus either sorafenib or placebo
|
| To see if the addition of sorafenib to capecitabine makes a more effective treatment for locally advance or metastatic HER2-negative breast cancer |
| |
| 2011.053.N - Multiple Myeloma (Asymptomatic High-Risk Smoldering) and the effects of Lenalidomide
|
This phase III trial is studying lenalidomide to see how well it works compared to observation in treating patients with asymptomatic high-risk smoldering multiple myeloma.
|
| |
| 2011.054.N - Invasive Breast Cancer and the effects of Trastuzumab
|
| This randomized phase III clinical trial is studying chemotherapy with or without trastuzumab after surgery to see how well they work in treating women with invasive breast cancer. |
| |
| 2011.083.A - Solid Tumor or Hematologic Malignancy and the effects of Inactivated Varicella-zoster Vaccine (VZV)
|
| This is a randomized, double-blind, placebo-controlled study to assess the safety and tolerability of V212 when administered to adults with solid tumor malignancy (STM) or hematologic malignancy (HM) and to determine whether V212 reduces the incidence of herpes zoster (HZ) in adults with STM or HM, as compared to placebo. |
| |
| 2011.090.N - Cervical Cancer and the effects of Paclitaxel and Cisplatin or Topotecan With or Without Bevacizumab
|
| This randomized phase III trial is studying the side effects of paclitaxel when given together with cisplatin or topotecan with or without bevacizumab and to compare how well they work in treating patients with stage IVB, recurrent, or persistent cervical cancer. |
| |
| 2011.094.A - Pancreatic Neuroendocrine Tumors and the effects of Everolimus and Octreotide with Bevacizumab
|
This randomized phase II trial is studying how well giving everolimus and octreotide together with or without bevacizumab works in treating patients with locally advanced or metastatic pancreatic neuroendocrine tumors that cannot be removed by surgery.
|
| |
| 2011.098.C - Gastric, Esophageal, and Gastroesophageal Cancer and the Effects of Ramucirumab
|
The purpose of this study is to determine whether ramucirumab when used in conjunction with chemotherapy treatment can help patients with stomach, esophagus and gastroesophageal cancer.
|
| |
| 2011.103.B - Studying First-Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-World Setting (SIMPLICITY)
|
| The purpose of this study is to better understand the use of tyrosine kinase inhibitors (TKI) in patients newly diagnosed with CML and their quality of life in a real-world setting. |
| |
| 2011.113.N - High-Risk Stage III or Stage IV Melanoma and the effects of Ipilimumab or High-Dose Interferon Alfa-2b
|
| This phase III clinical trial is studying ipilimumab or high-dose interferon alfa-2b in treating patients with high-risk stage III or stage IV melanoma that has been removed by surgery. |
| |
| 2011.137.A - Pelvic Radiation Therapy and the Effects of Sulfasalazine in Preventing Acute Diarrhea
|
| This randomized phase III trial is studying sulfasalazine to see how well it works in preventing acute diarrhea in patients with cancer who are undergoing pelvic radiation therapy. |
| |
| 2011.150.C - Brain Tumors and the effects of Armodafinil in Treating Fatigue
|
This clinical trial is studying how well armodafinil works in treating fatigue caused by radiation therapy in patients with primary brain tumors.
|
| |
| 2011.151.A - Prostate Cancer and the Effects of L-Arginine Supplementation
|
| This randomized phase II trial is studying how well L-arginine supplementation works with or without enzyme inhibitors in treating erectile function and quality of life of prostate cancer survivors previously treated with radiation therapy. |
| |
| 2011.151.C - Acute Myeloid Leukemia and the effects of Vosaroxin and Cytarabine
|
| This study will compare the overall survival (OS) between treatment groups of patients treated with vosaroxin and cytarabine versus patients treated with placebo and cytarabine. |
| |
| 2011.154.A - Recurrent Epithelial Ovarian Cancer and the Effects of Paclitaxel
|
| OSI-906-202- A Phase 1/2 Study Evaluating Intermittent and Continuous OSI-906 and Weekly Paclitaxel in Patients With Recurrent Epithelial Ovarian Cancer (and Other Solid Tumors) Richard Kline, M.D. 2011.154.A Open to new patients 1 This is a multi-center, randomized, open-label, phase 1/2 study of continuous w |
| |
| 2011.188.N - S1007- Invasive Breast Cancer and the effects of Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane
|
| A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and Her2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less Greg Bizette, M.D. 2011.188.N Open to new patients 3 This phase III clinical tr |
| |
| 2012.021.N - Protocol for the Enrollment on the Official COG Registry
|
| The Children's Oncology Group (COG) has established a research network, known as the Childhood Cancer Research Network (CCRN), for collecting information about children & young adults with cancer and other conditions that are characterized by abnormal cell growth but are benign (not cancer) in order to help doctors and scientists better understand childhood cancer. The goal is to have clinical information about every child & young adult diagnosed with cancer and other conditions that are characterized by abnormal cell growth in the United States and Canada. This information can then be used by researchers to answer questions such as whether childhood cancer is increasing across the United States or Canada, and whether there is a higher risk of cancer among some groups compared to others. The information can also help researchers study the causes of childhood cancer. |
| |
| 2012.022.N - Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma
|
AOST06B1-A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
Rajasekharan Warrier, M.D. 2012.022.N Open to new patients Not Applicable The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma. DISEASE |
| |
| 2012.022.N - Study of Kidney Tumors in Young Patients
|
| This laboratory study is looking at kidney tumors in young patients. |
| |
| 2012.024.N - Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
|
| This research study is collecting and storing samples of tumor tissue, bone marrow, and blood from patients with Ewing sarcoma. |
| |
| 2012.026.N - Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
|
| AALL08B1- Classification of Newly Diagnosed Acute Lymphoblastic Leukemia Rajasekharan Warrier, M.D. 2012.026.N Open to new patients Not Applicable This research study is developing a risk-based classification system for patients with newly diagnosed acute lymphoblastic leukemia. DISEASE CHARACTERISTICS: |
| |
| 2012.046.N - Wilms Tumor and the Effects of Vincristine, Dactinomycin, and Doxorubicin
|
| This phase III trial is studying vincristine, dactinomycin, and doxorubicin with or without radiation therapy or observation only to see how well they work in treating patients undergoing surgery for newly diagnosed stage I, stage II, or stage III Wilms' tumor. |
| |
| 2012.051.N - Nonmetastatic Extracranial Ewing Sarcoma and the Effects of Combination Chemotherapy
|
| This randomized phase III trial is studying combination chemotherapy in treating patients with non-metastatic extracranial Ewing sarcoma. |
| |
| 2012.059.N - Newly Diagnosed Stage III or Stage IV Wilms Tumor Combination Chemotherapy
|
| This phase III trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with newly diagnosed stage III or stage IV Wilms tumor. |
| |
| 2012.086.N - Lymphoblastic Leukemia and the effects of Risk-Adapted Chemotherapy
|
| This partially randomized phase III clinical trial is studying different combinations of risk-adapted chemotherapy regimens and their side effects and comparing how well they work in treating younger patients with newly diagnosed standard-risk acute lymphoblastic leukemia. |
| |
| 2012.090.N - Endometrial Carcinoma and the Effects of Carboplatin and Paclitaxel
|
| This randomized phase III trial is studying carboplatin and paclitaxel to see how well they work when given with or without cisplatin and radiation therapy in treating patients with stage I, stage II, stage III, or stage IVA endometrial cancer. |
| |
| 2012.091.N - Ovarian Cancer and the Effects of Paclitaxel and Carboplatin
|
| This randomized phase III trial is studying giving paclitaxel together with carboplatin to see how well it works compared with giving paclitaxel together with ifosfamide in treating patients with newly diagnosed persistent or recurrent uterine or ovarian cancer. |
| |
| 2012.092.B - Breast Cancer and the Effects of Genetic Susceptibility to Radiation-Induced Skin Reactions
|
| This clinical trial studies genetic susceptibility to radiation-induced skin reactions in racial/ethnic groups of patients with breast cancer. |
| |
| Colorectal Cancer and the Effects of Irinotecan Hydrochloride and Cetuximab
|
| This randomized phase II trial is studying the side effects and how well giving cetuximab and irinotecan hydrochloride with or without ramucirumab work in treating patients with advanced colorectal cancer with progressive disease after treatment with bevacizumab-containing chemotherapy. |
| |