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Clinical Trial Listing

2002.354.C - Gastrointestinal Motility Disorder and the effects of Cisapride 
This study seeks to provide an alternative to patients who have failed standard therapy and have no therapeutic options.
 
2003.123.B - Strokes and the effects of Closure of Patent Foramen Ovale 
To determine whether closure of PFO is superior  to medical therapy is subjects who have had a stroke with PFO as the only risk factor.
 
2003.129.B - Colon and Rectal Surgery and the effects of Mechanical Bowel Preparation 
This study seeks to determine if elective colon and rectal resection surgery can be safely performed without bowel preparation.
 
2003.845.W - Fecal Incontinence and the effects of Medtronic InterStim Therapy 
This study is assessing the safety and effectiveness of stimulating the sacral nerve using the Medtronic InterStim Therapy for patients with fecal incontinence.
 
2004.121.A - Knee Injuries and Chondral Lesions 
This study is aimed at identifying patients with a defect in the articular surface of the knee and then correlate the location of the defect(s) to the type of limitations these patients have in performing normal and/or sports-related activities.
 
2006.044.B - Kidney Transplant and the effects of ISA247 and Tacrolimus 
The purpose is to evaluate the safety and effectiveness of a new immunosuppressant drug in post kidney transplant patients
 
2006.062.C - Femoral Artery Blockage and the effects of Covered vs. Bare Stents 
The purpose of this study is to collect long-term information on the performance of the GORE VIABAHN® Endoprosthesis (covered stent) as compared to bare metal stents for the treatment of narrowing or blockages of the femoral artery which supplies blood flow to the lower leg and foot.
 
2006.164.A - Migraines and the effects of the AMPLATZER PFO Occluder 
This study is seeking to treat patients who have treatment resistant migraines who also have a Patent Foramen Ovale.
 
2006.165.B - Parkinson's Disease and the effects of a Dopamine-Agonist Patch 
The study is monitoring the effectiveness of a dopamine-agonist in the form of a 24-hour continuous delivery patch for Parkinson's disease.
 
2006.177.C - Diabetes (Type 2) and the effects of Insulin Inhalation Powder 
This study is comparing two different doses of an experimental drug to see which is more effective in treating type 2 diabetes mellitus.
 
2007.004.A - Parkinson's and the effects of Creatine 
To evaluate creatine as a potential neuroprotective substance
 
2007.192.A - Post-Katrina New Orleans: Mold Exposure and Allergic Response 
To learn more about the relationship between Katrina-related environmental exposures and the presence of allergies among a sample of patients living in the Greater New Orleans area, post-Katrina.
 
2008.009.A - Chronic Kidney Disease and the effects of AST-120 
The purpose of this study is to evaluate  the effectiveness of AST-120 added to standard-of-care therapy to prolong the time of initiation of dialysis, kidney transplantation, or serum-creatinine doubling in the blood as compared to baseline.
 
2008.077.A - Liver Tissue Donation 
Excess liver tissue removed at transplant will be used to study hepatitis C.
 
2008.087.C - Shoulder Osteoarthritis and the effects of Orthovisc® vs Corticosteroid Injection 
A comparison of Orthovisc® to Corticosteroid Injection in shoulder osteoarthritis.
 
2008.088.C - Venous Thromboembolic Events and the effect of Rivaroxaban vs Enoxaparin 
The objective of this study is to demonstrate the superior efficacy of VTE prophylaxis with oral rivaroxaban 10 mg once daily administered for 354 days to SC enoxaparin 40 mg once daily (OD) administered for 104 days in men and women aged 40 years or above who have been hospitalized for a medical illness.
 
2008.091.B - Cardiac Surgery and the effects of the ON-Q Pain Pump 
The purpose of the study is to observe whether infection rates are lower in a group of people whose pain after surgery is treated with an infusion of anesthetic through a pain pump versus standard pain management.
 
2008.100.A - PriSm and the effects of Strattice Mesh 
To study the effectiveness of Strattice (a mesh overlay) in preventing hernias in patients getting a permanant ostomy (opening in the abdominal wall where the bowel is attached).
 
2008.104.C - Parkinson's (new onset) and the effects of CoQ10 
Purpose - To Find a Neuro-Protective Drug
 
2008.107.A - Renal Impairment and Invasive Fungal Infection and the effects of Isavuconazole 
Treatment of invasive infections caused by rare molds, yeasts, and fungi
 
2008.127.N - Stage 1 Non-Small Cell Lung Cancer and the Effects of Different Types of Surgery 

Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer. This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer.


 
2008.132.B - Diabetes (Type 2 treated with Metformin and Pioglitazone) and the effects of Taspoglutide 
A multicenter, randomized, double blind, placebo controlled study to assess the efficacy, safety and tolerability of taspoglutide (RO5073031) compared to placebo, in patients with type 2 diabetes mellitus inadequately controlled with metformin plus pioglitazone Lawrence
 
2008.135.C - Emergence Delirium and the effects of Pressure Equalization Tubes 
The purpose is to evaluate the use of intranasal dexmedetomidine to reduce the incidence of emergence delirium during general sevoflurane anesthesia in a pediatric population receiving pressure equalization tubes in one or both ears.
 
2008.147.B - Eye Function and the effects of Linezolid (Zyvox) 
To prospectively indentify and characterize optic nerve toxicity in subjects receiving long-term (2 months or greater) linezolid (zyvox) therapy.
 
2008.162.A - Invasive Candidiasis in children and the effects of Anidulafungin 
The purpose of this study is to determine the safety, efficacy and exposure (blood levels) of anidulafungin when used to treat children between the ages of 1 month and less than 18 years with invasive Candida infections.
 
2008.165.A - CRT and the effects of OPTIMISE 
Demonstrate that the QuickOpt method provides simple, practical method to enhance clinical response to CRT.
 
2009.134.C - Crohn's Disease and the effects of Cimzia 
The purpose of this observational registry is to collect information on the long-term use and safety of Cimzia® as compared to other Crohn’s disease medications prescribed by your doctor in routine clinical practice.
 
2010.011.N - Prostate Cancer and the effects of Radiation Therapy with or without Androgen-Deprivation Therapy 
This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer.
 
2010.037.B - Gastrointestinal Disorders and the effects of Domperidone 
The purpose of this expanded access program is to provide oral domperidone in the United States to patients for the relief of gastrointestinal (GI) symptoms associated with gastrointestinal motility disorders after currently approved treatments have not worked.   
 
2010.040.N - NSABP B-43 - Ductal Carcinoma In Situ and the effects of Radiation Therapy with or without Trastuzumab 
This randomized phase III trial is studying radiation therapy to see how well it works compared with or without trastuzumab in treating women with ductal carcinoma in situ who have undergone lumpectomy.
 
2010.055.B - Kidney Transplant and an observation of Hyperparathyroidism 
To better understand the progression of Hyperparathyroidism among kidney transplant recipients
 
2010.069.A - Children with Fever and the effects of IV Ibuprofen 
The purpose of this study is to compare acetaminophen (tylenol) orally or as a suppository to intravenous (IV) ibuprofen in children
 
2010.084.N - Pancreas and the effects of Erlotinib and Chemoradiation 
This randomized phase III trial is studying gemcitabine hydrochloride and erlotinib hydrochloride to see how well they work compared with gemcitabine hydrochloride alone followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil in treating patients with pancreatic cancer that was removed by surgery.
 
2010.084.N - Pancreatic Cancer and the Effects of Both Erlotinib and Chemoradiation as Adjuvant Treatment After Resection 

This randomized phase III trial is studying gemcitabine hydrochloride and erlotinib hydrochloride to see how well they work compared with gemcitabine hydrochloride alone followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil in treating patients with pancreatic cancer that was removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, capecitabine, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells. Giving chemotherapy together with or without erlotinib hydrochloride and/or radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether chemotherapy is more effective when given with or without erlotinib hydrochloride and/or radiation therapy in treating pancreatic cancer

 

 

 
2010.096.N - Liver Cancer and the effects of Sorafenib Tosylate and Doxorubicin Hydrochloride 
Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving sorafenib tosylate together with doxorubicin hydrochloride is more effective than sorafenib tosylate alone in treating liver cancer.
 
2010.097.B - Perioperative Cardiovascular Events and the effects of Clonidine and/or Aspirin 
The purpose of this study is to determine whether two drugs, aspirin and/or clonidine, reduce the risk of heart attack and death after surgery in patients at risk for heart disease.
 
2010.132.C - Diabetes (Type 2) and the effects of LY2189265 vs. insulin glargine 
Blood sugar improvement
 
2010.147.A Tonsillectomy or Tonsillectomy/ Adenoidectomy in children and their response to pain 
The purpose of this study is to analyze a blood sample from children having for factors that may be associated with how children respond to pain.
 
2010.154.N - Lung Cancer and the effects of Carboplatin and Paclitaxel with or without Bevacizumab and/or Cetuximab 
This randomized phase III trial is studying carboplatin and paclitaxel to compare how well they work with or without bevacizumab and/or cetuximab in treating patients with stage IV or recurrent non-small cell lung cancer.
 
2010.156.N - Colon Cancer and the effects of Celecoxib 
This randomized phase III trial is studying giving oxaliplatin, leucovorin calcium, and fluorouracil together to compare how well they work when given together with or without celecoxib in treating patients with stage III colon cancer previously treated with surgery.
 
2010.170.N - Lung Cancer (NSCLC) and the effects of Bevacizumab or Pemetrexed Disodium with Induction Therapy 
This randomized phase III trial is studying bevacizumab and pemetrexed disodium alone or in combination after induction therapy to see how well they work in treating patients with advanced non-squamous non-small cell lung cancer.
 
2010.172.N - Small-Cell Lung Cancer Receiving and the Effects of Radiation Therapy Regimens 

This randomized phase III trial is comparing three different chest radiation therapy regimens to see how well they work in treating patients with limited-stage small cell lung cancer.


 
2010.177.C - Advanced Heart Failure and the effects of the HeartWare Ventricular Assist System 
This study is for patients who are eligible to receive a ventricular assist device.  Patients will be randomized (like the toss of a coin) to receive either the HeartWare Ventricular Assist System or a control Left Ventricular Assist Device.
 
2010.186.B - Heart Failure and the effects of the St. Jude Medcial CRT 
Predict response to CRT-D per-implant, determine if combined use of certain blood draws can further predict & improve Heart Failure
 
2010.208.N - Prostate Cancer (with a Rising PSA After Radical Prostatectomy) and the effects of Short-Term Androgen Deprivation With Pelvic Lymph Node or Prostate Bed-Only Radiotherapy (SPPORT) 

This randomized phase III trial is studying prostate radiation therapy to see how well it works compared with short-term androgen deprivation therapy given together with pelvic lymph node radiation therapy with or without prostate radiation therapy in treating patients with a rising PSA after surgery for prostate cancer.

 


 
2011.001.A - Heart Failure and the effects of the Optimizer Heart Failure Device 
To evalute the effectivenes and safety of the Optimizer device in heart failure patients.
 
2011.002.B - Coronary lesions and the effects of an Orbital System treatment 
Some people have severely calcified lesions in the blood vessels of the heart. These lesions narrow the blood vessels and cause heart problems. The Diamondback 360° Orbital Atherectomy System is a system used to treat the lesions in the blood vessels of the heart. It is used to widen these vessels to assist in stent placement. (A stent is a tube which keeps the vessel open.) We are studying how well this system works.
 
2011.006.B - Aortic Stenosis and the Use of Edwards SAPIEN XT Aortic Transcatheter Valves 
The purpose is to determine the safety and effectiveness of the Edwards SAPIEN XT™ device (an artificial heart valve) and the Edwards NovaFlex delivery system in inoperable patients with symptomatic critical aortic stenosis.
 
2011.018.B - Femoropopliteal Lesions and the Effects of the Innova Nitinol Stent System 
When a person has a lesion or blockage in a blood vessel, often the doctor will recommend that the blockage be treated using a stent (a thin metal tube) to hold the blood vessel open for better blood flow. The purpose of this study is to learn whether the investigational INNOVA™ Nitinol Stent System is safe and if it works for opening the blocked or narrowed superficial femoral artery or proximal popliteal artery blood vessels of the upper leg in patients with peripheral artery disease.
 
2011.054.N - Invasive Breast Cancer and the effects of Trastuzumab 
This randomized phase III clinical trial is studying chemotherapy with or without trastuzumab after surgery to see how well they work in treating women with invasive breast cancer.
 
2011.080.B Carotid stenting procedure and the effects of two embolic protection devices 
To collect data about the Gore Flow Reversal System or the Gore Embolic Filter during Carotid Stent Procedures.
 
2011.113.N - High-Risk Stage III or Stage IV Melanoma and the effects of Ipilimumab or High-Dose Interferon Alfa-2b 
 This phase III clinical trial is studying ipilimumab or high-dose interferon alfa-2b in treating patients with high-risk stage III or stage IV melanoma that has been removed by surgery.
 
2011.188.N - S1007- Invasive Breast Cancer and the effects of Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane 
A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and Her2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less Greg Bizette, M.D. 2011.188.N Open to new patients 3 This phase III clinical tr
 
2012.014.A - Follicular Lymphoma and the Effects of Combined Rituximab and Lenalidomide Treatment 

The purpose of this study is to evaluate the effect of the combined treatment of lenalidomide and rituximab in controlling the Follicular Lymphoma disease and also increase the length of response compared to the available standard combination chemotherapy treatment for Follicular Lymphoma.


 
2012.015.N - Oropharynx Cancer and the Effects of Radiotherapy Plus Cetuximab vs. Chemoradiotherapy (RTOG 1016) 

Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective with cisplatin or cetuximab in treating oropharyngeal cancer. This phase III trial is studying radiation therapy with cisplatin or cetuximab to see how well it works in treating patients with oropharyngeal cancer.


 
2012.041.A - Uncontrolled Hypertension and the effects of the Renal Denervation Procedure 
To demonstrate the safety and effectiveness of renal denervation in lowering blood pressure in patients with uncontrolled hypertension (blood pressure >160/90)
 
2012.086.N - Lymphoblastic Leukemia and the effects of Risk-Adapted Chemotherapy 
This partially randomized phase III clinical trial is studying different combinations of risk-adapted chemotherapy regimens and their side effects and comparing how well they work in treating younger patients with newly diagnosed standard-risk acute lymphoblastic leukemia.
 
2012.090.N - Endometrial Carcinoma and the Effects of Carboplatin and Paclitaxel 
This randomized phase III trial is studying carboplatin and paclitaxel to see how well they work when given with or without cisplatin and radiation therapy in treating patients with stage I, stage II, stage III, or stage IVA endometrial cancer.
 
2012.091.N - Ovarian Cancer and the Effects of Paclitaxel and Carboplatin 
This randomized phase III trial is studying giving paclitaxel together with carboplatin to see how well it works compared with giving paclitaxel together with ifosfamide in treating patients with newly diagnosed persistent or recurrent uterine or ovarian cancer.
 
2012.093.N - Esophageal Cancer and the Effects of Traztuxumab to treatment for HER2-Overexpressing Tmors 
This randomized phase III trial is studying how well giving radiation therapy, paclitaxel, and carboplatin together with or without trastuzumab works in treating patients with esophageal cancer.
 
2012.103.A - Arthralgia induced by AIs and the Effects of Subcutaneous Testosterone 

Testosterone may help relieve moderate or severe arthralgia associated with the use of aromatase inhibitors, such as anastrozole or letrozole. This randomized phase III trial studies testosterone to see how well it works compared to placebo in treating postmenopausal patients with arthralgia caused by anastrozole or letrozole.


 
2012.115.N - Cervical Cancer and the Effects of Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel 
This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with locally advanced cervical cancer.
 
2012.117.N - Hepatocellular Cancer and the Effects of Chemoembolization With or Without Sorafenib 
This randomized phase III trial is studying chemoembolization and sorafenib tosylate to see how well they work compared with chemoembolization alone in treating patients with liver cancer that cannot be removed by surgery
 
2012.118.N - Rectal Cancer and The Effects of Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients Undergoing Surgery 

Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy alone is more effective then chemotherapy plus radiation therapy in treating rectal cancer. This randomized phase II/III trial studies how well chemotherapy alone compared to chemotherapy plus radiation therapy works in treating patients with rectal cancer undergoing surgery

 

 
2012.129.N - B-precursor ALL and the Effectts of Clofarabine in the Very High Risk Stratum 
This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed high-risk acute lymphoblastic leukemia.
 
2012.160.A - Chemo-Inducted Nausea and Vomiting and the Effects of IV Fosaprepitant Dimeglumine 

This study aims to demonstrate that, when given concomitantly with a 5-hydroxytryptamine 3 (5-HT3) antagonist and a corticosteroid, a single 150 mg intravenous (IV) dose of fosaprepitant given on Day 1 is superior to the control regimen of 5-HT3 and corticosteroid only, in preventing chemotherapy-induced nausea and vomiting (CINV) associated with moderately emetogenic chemotherapy (MEC).

 
2012.168.N - Collecting and Storing Tissue for Young Patients With Cancer 
This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer.
 
2012.169.N - AML and the Effects of Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients 
This randomized phase III clinical trial is studying caspofungin acetate to see how it works compared to fluconazole in preventing invasive fungal infections in patients with acute myeloid leukemia who are undergoing chemotherapy.
 
2012.170.N - Pediatric ALL and Compliance With Mercaptopurine Treatment 
This randomized clinical trial is assessing compliance to a mercaptopurine treatment intervention compared to standard of care in younger patients with acute lymphoblastic leukemia in remission.
 
2012.186.N - AML or Stem Cell Transplant Patients and the Effects of Levofloxacin in Preventing Infection 
This randomized phase III trial studies how well levofloxacin works in preventing infection in young patients with acute leukemia receiving chemotherapy or undergoing stem cell transplant. Giving antibiotics may be effective in preventing or controlling early infection in patients receiving chemotherapy or undergoing stem cell transplant for acute leukemia
 
2012.209.A - Metastatic HER2-, Hormone + Breast Cancer and the Effects of BKM120 With Fulvestrant (BELLE3) 

This study will evaluate whether the addition of daily BKM120 to fulvestrant is effective and safe in treating patients with HR+, HER2-, AI treated locally advanced or metastatic breast cancer who progressed on or after mTor inhibitor based treatment.


 
2012.214.N - Hepatoblastoma and the Effects of Combination Chemotherapy 
This phase III trial is studying the side effects of giving doxorubicin hydrochloride together with combination chemotherapy and to compare different chemotherapy regimens to see how well they work in treating young patients with newly diagnosed liver cancer.
 
2013.031.B - Mantle Cell Lymphoma and the Effects of Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide 
This randomized phase II trial studies rituximab, bortezomib, bendamustine, and lenalidomide in treating previously untreated older patients with mantle cell lymphoma.
 
2013.042.C - Endometrial and Cervical Cancer and the Effect of Standard Versus Intensity-Modulated Pelvic Radiation Therapy 
This randomized phase III trial is studying two different methods of radiation and their side effects and comparing how well they work in treating endometrial and cervical cancer after surgery.
 
2013.070.A - Melanoma and the Effect of Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b 

This randomized phase II trial studies how well ipilimumab with or without high-dose recombinant interferon alpha-2b works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Recombinant interferon alfa-2b may interfere with the growth of tumor cells. It is not yet known whether ipilimumab is more effective with or without high-dose recombinant interferon alfa-2b in treating melanoma


 
2013.091.A - Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy 
This randomized phase III trial is studying how well acupressure wristbands work with or without standard care in controlling nausea in young patients receiving highly emetogenic chemotherapy.
 
2013.147.B - Pancreatic Neuroendocrine tumor and the effects of Temozolomide With or Without Capecitabine 

This randomized phase II trial studies how well giving temozolomide with or without capecitabine works in treating patients with advanced pancreatic neuroendocrine tumors. Drugs used in chemotherapy, such as temozolomide and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether temozolomide is more effective with or without capecitabine in treating patients with advanced pancreatic neuroendocrine tumors.


 
2013.162.N - Prostate Cancer and the Effects of Androgen-Deprivation Therapy and Radiation Therapy 

Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells. This randomized phase III trial studies androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer.


 
2013.165.N - High-Risk Prostate Cancer and the Effects of Hormone Therapy, Radiation Therapy, and TAK-700 

Androgens can cause the growth of prostate cancer cells. Drugs, such as steroid 17alpha-monooxygenase TAK-700, when used with other hormone therapy, may lessen the amount of androgens made by the body. Radiation therapy uses high energy x rays to kill tumor cells. This may be an effective treatment for prostate cancer when combined with hormone therapy. Studying quality-of-life in patients having cancer treatment may help identify the intermediate- and long-term effects of treatment on patients with prostate cancer.  This randomized phase III trial is studying the use of hormone therapy, including TAK-700, together with radiation therapy in treating patients with prostate cancer.


 
2013.262.B - Myeloma and the Effects of Conventional Dose Treatment vs. High-Dose Treatment + Peripheral Stem Cell Transplant 

The drugs, lenalidomide, bortezomib, and dexamethasone, are approved by the FDA. They have not been approved in the combination for multiple myeloma or any other type of cancer. Bortezomib is currently approved by the FDA for the treatment of multiple myeloma. Lenalidomide is approved for use with dexamethasone for patients with multiple myeloma who have received at least one prior therapy and for the treatment of certain types of myelodysplastic syndrome (another type of cancer affecting the blood). Dexamethasone is commonly used, either alone, or in combination with other drugs, to treat multiple myeloma. Please note that Bortezomib and Lenalidomide are provided to patients participating in this trial at no charge. Melphalan and cyclophosphamide, the drugs used during stem cell collection and transplant, are also approved by the FDA. Melphalan is an FDA-approved chemotherapy for multiple myeloma and is used as a high-dose conditioning treatment prior to stem cell transplantation. Cyclophosphamide is used, either alone, or in combination with other drugs, to treat multiple myeloma. These drugs have been used in other multiple myeloma studies and information from those studies suggests that this combination of therapy may help to treat newly diagnosed multiple myeloma.

In this research study, we are looking to explore the drug combination, lenalidomide, bortezomib and dexamethasone alone or when combined with autologous stem cell transplantation to see what side effects it may have and how well it works for treatment of newly diagnosed multiple myeloma. Specifically, the objective of this trial is to determine if, in the era of novel drugs, high dose therapy (HDT) is still necessary in the initial management of multiple myeloma in younger patients. In this study, HDT as compared to conventional dose treatment would be considered superior if it significantly prolongs progression-free survival by at least 9 months or more, recognizing that particular subgroups may benefit more compared to others.


 
2014.008.N - Metastatic Pancreatic Neuroendocrine Tumors to the Liver and the Effects of Adjuvant Everolimus (E2212) 

This randomized phase II trial studies how well everolimus works in treating patients with pancreatic neuroendocrine tumors metastatic to the liver previously treated with surgery. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving everolimus after surgery may kill any tumors cells that remain.


 
2014.013.N - Renal Cancer and the Effects of Everolimus after Surgery 

Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor. This phase III trial is studying everolimus to see how well it works in treating patients with kidney cancer who have undergone surgery.


 
2014.059.N - Non-Metastatic Desmoplastic Medulloblastoma and the Effects of Combination Chemo for Younger Patients 

This phase II trial studies how well combination chemotherapy works in treating younger patients with newly diagnosed, non-metastatic desmoplastic medulloblastoma. Drugs used in chemotherapy, such as vincristine sulfate, cyclophosphamide, methotrexate, etoposide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.


 
2014.079.N - Hormone Receptor, HER2 Positive Breast Cancer and the Effects of Neoadjuvant Therapy with or without Estrogen Deprivation 
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive, operable or locally advanced breast cancer.
 

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